Estimated HIV transmission risk per exposure from an HIV-positive individual who is NOT on suppressive ART: - Human bite < 1 in 10,000 - Receptive oral sex (giving fellatio) < 1 in 10,000 - Insertive oral sex (receiving fellatio) < 1 in 10,000 - Receptive vaginal intercourse 1 in 1000 - Insertive vaginal intercourse 1 in 1,219 - Insertive anal intercourse and circumcised 1 in 909 - Insertive anal intercourse not circumcised 1 in 161 - Receptive anal intercourse no ejaculation 1 in 170- Receptive anal intercourse with ejaculation 1 in 65 PEP to be offered routinely: 1) Following receptive anal intercourse with an index partner of unknown HIV status or known to be HIV positive with an unknown or detectable HIV viral load. 2) Following receptive vaginal sex with an index partner known to be HIV positive with an unknown or detectable HIV viral load. 3) Following an occupational exposure (sharps or mucosal splash) from an index case known to be HIV positive with an unknown or detectable HIV viral load. 4) For people who inject drugs after sharing needles/equipment if their index injecting partner is known to be HIV positive with an unknown or detectable HIV viral load. PEP to be considered if: 1) Insertive vaginal intercourse with an index partner known to be HIV-positive with an unknown or detectable HIV viral load. 2) Insertive anal intercourse with an index partner of unknown HIV status. Reference(s): BASHH: UK Guideline For The Use Of HIV Post-Exposure Prophylaxis 2021